Dosing of cephalosporines in renal failure pateints Research Proposal

Dosing of cephalosporines in renal failure pateints - Research Proposal ExampleAim- To understand the dosing of Cephalosporin in Renal failure patients. Method and end Physical examination- should be performed for edema, ascites, dehydration. Measurement of body weight and height is performed. In obese patients the ideal body weight should be calculated and dose of do drugs should be planned consequently. Renal function- Estimation of creatine clearance (the volume of blood plasma that is cleared of creatinine in a unit time). Elimination of drugs is straight proportional to GFR (drugs excreted by kidneys). The Cockroft- Gault equation to estimate Clcr for age between 40- 80 years. Clcr (mL/min) = (140-age)x weight in kgs / 72 x serum creatinine (in mg/ dL) x (0.85 for women). mind of GFR from serum creatinine level presumes the stability of renal function and also formulate that serum creatinine measurement is constant. If there is alteration in renal function, the creatinine lev el does non indicate the true clearance. In case of oliguria, Clcr is approximated as 10mL/min. In cases with acute renal failure, the non-renal clearance of medicines diminishes by means of time window of renal failure. In the initial course of the therapy, personalized pharmacokinetic dose for patients with severe renal impairment is vital.